Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells

FEBS Letters

Oishi, Michio¹  Gebbink, Martijn F.B.G.²  Kume, Tsutomu¹  Thomas, Matthew L.³  Tsuneizumi, Kazuhide¹  Watanabe, Toshio¹ 

[1] Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan;Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands;Howard Hughes Medical Institute and Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA

关键词: Differentiation;    Protein tyrosine phosphatase;    Embryonal carcinoma cell;   

DOI  :  10.1016/0014-5793(94)00491-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have investigated the pattern of PTPase transcript expression during in vitro differentiation of mouse embryonal carcinoma (F9) cells. While the transcripts of most PTPases were unchanged or undetected during embryonal differentiation induced by retinoic acid, several PTPase transcripts exhibited distinct patterns of induction. Mutant cells defective in differentiation did not display the induction of some of these PTPase transcripts. Interestingly, three out of the four PTPase transcripts induced were the same PTPase transcripts induced during in vitro erythroid differentiation of mouse erythroleukemia (MEL) cells [(1982) Biochem. Biophys. Res. Commun. 107, 1104–1109]. The possible role played by specific PTPases in cell differentiation is discussed.

【 授权许可】

Unknown