Thermodynamic considerations on the formation of reactive species from hypochlorite, superoxide and nitrogen monoxide Could nitrosyl chloride be produced by neutrophils and macrophages?

FEBS Letters

Koppenol, W.H.¹ 

[1] Departments of Chemistry and Biochemistry, and Biodynamics Institute, Louisiana State University, Baton Rouge, LA 70803, USA

关键词: Hypochlorite;    Nitric oxide;    Peroxynitrite;    Nitrosyl chloride;    Neutrophil;    Macrophage;   

DOI  :  10.1016/0014-5793(94)00494-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Hypohalous acids are poor one-electron oxidizing agents, such that reactions with hydrogen peroxide to yield radical species are not feasible. However, the oxidation of superoxide by hypohalous acids can be a source of hydroxyl or haline radicals. The oxidation of nitrogen monoxide by hypochlorous acid is favourable, but in all likelihood cannot compete with the diffusion-controlled reaction with superoxide to yield peroxynitrite. The reaction of the latter with hypochlorous acid may lead to nitrosyl chloride, a strongly oxidizing agent [E°′(NOCl/NO•, Cl) = 1.0 V] that is capable of nitrosylating organic compounds and thereby generating mutagens or promutagens.

【 授权许可】

Unknown