The antioxidant properties of carnitine in vitro

Cellular & Molecular Biology Letters

Katarzyna Solarska³  Anna Lewińska³  Agata Karowicz-Bilińska¹  Grzegorz Bartosz² 

[1] Clinic of High-Risk Pregnancy, Medical University of Łódź, Łódź, Poland$$;Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland$$Department of Molecular Biophysics, University of Łódź, Łódź, Poland$$;Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland$$

关键词: Antioxidant;    Carnitine;    Hydrogen peroxide;    Hypochlorite;    Peroxyl radical;    Peroxynitrite;   

DOI  :  10.2478/s11658-009-0036-y

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Many of the effects of carnitine are ascribed to its antioxidant properties. The aim of this study was to evaluate the antioxidant properties of carnitine in vitro. Carnitine was found to decolorize ABTS•+, and to protect fluorescein against bleaching induced by AAPH-derived peroxyl radicals and peroxynitrite, thiol groups against oxidation induced by hydrogen peroxide, peroxyl radicals, hypochlorite and peroxynitrite, and erythrocytes against hemolysis induced by peroxyl radicals and hypochlorite. These results show that carnitine has a direct antioxidant action against physiologically relevant oxidants.

【 授权许可】

Unknown