Protein translocation: Common themes from bacteria to man

FEBS Letters

Hartmann, Enno¹  Rapoport, Tom A.¹  Jungnickel, Berit¹ 

[1] Max-Delbrück Center for Molecular Medicine, Robert-Rössle Str. 10, 13122 Berlin-Buch, Germany

关键词: Protein transport;    Endoplasmic reticulum;    Secretion;    Membrane biosynthesis;   

DOI  :  10.1016/0014-5793(94)00367-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Protein transport across the endoplasmic reticulum membrane in eukaryotes and across the cytoplasmic membrane in bacteria have turned out to be highly related. The core component of the translocation apparatus is the Sec61/SecYp complex; at least two of its subunits are conserved in evolution. The Sec61/SecYp complex is involved in both co- and post-translational transport pathways. The two modes require probably distinct additional components.

【 授权许可】

Unknown