FEBS Letters | |
Regulation of interleukin‐6 receptor expression by interleukin‐6 in human monocytes — a re‐examination | |
Heinrich, Peter C.1  Graeve, Lutz1  Schoester, Monika1  | |
[1] Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, 52057 Aachen, Germany | |
关键词: Interleukin-6; Cytokine receptor; Lipopolysaccharide; Monocyte; IL-6; interleukin-6; IL-6-R; interleukin-6-receptor; LPS; lipopolysaccharide; TGF-β1; transforming growth factor-β1; | |
DOI : 10.1016/0014-5793(94)00416-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We have studied the expression and regulation of the interleukin-6 receptor (gp80) and its signal transducer gp13O in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27–30] we find that neither lipopolysaccharide nor interleukin-6 (IL-6) lead to a down-regulation of IL-6 receptor mRNA in monocytes. Also in the human monocytic cell line Mono Mac 6 no effect of IL-6 on receptor mRNA levels was observed. For signal transducer gp13O mRNA in monocytes a small and transient up-regulation by IL-6 was found.
【 授权许可】
Unknown
【 预 览 】
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RO201912020299551ZK.pdf | 417KB | download |