Regulation of interleukin‐6 receptor expression by interleukin‐6 in human monocytes — a re‐examination

FEBS Letters

Heinrich, Peter C.¹  Graeve, Lutz¹  Schoester, Monika¹ 

[1] Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, 52057 Aachen, Germany

关键词: Interleukin-6;    Cytokine receptor;    Lipopolysaccharide;    Monocyte;    IL-6;    interleukin-6;    IL-6-R;    interleukin-6-receptor;    LPS;    lipopolysaccharide;    TGF-β1;    transforming growth factor-β1;   

DOI  :  10.1016/0014-5793(94)00416-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have studied the expression and regulation of the interleukin-6 receptor (gp80) and its signal transducer gp13O in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27–30] we find that neither lipopolysaccharide nor interleukin-6 (IL-6) lead to a down-regulation of IL-6 receptor mRNA in monocytes. Also in the human monocytic cell line Mono Mac 6 no effect of IL-6 on receptor mRNA levels was observed. For signal transducer gp13O mRNA in monocytes a small and transient up-regulation by IL-6 was found.

【 授权许可】

Unknown