期刊论文详细信息
FEBS Letters
cDNA cloning and regional distribution of a novel member of the opioid receptor family
Takeshima, Hiroshi1  Kato, Shigehisa3  Houtani, Takeshi4  Miyata, Takashi2  Iwabe, Naoyuki2  Sugimoto, Tetsuo4  Fukuda, Kazuhiko3  Nishi, Miyuki1  Mori, Kenjiro3 
[1] International Institute for Advanced Studies, Shimadzu N-80, Nishinokyo-Kuwahara-cho, Kyoto 604, Japan;Department of Biophysics, Kyoto University Faculty of Science, Kyoto 606-01, Japan;Department of Anesthesia, Kyoto University Hospital, Sakyo-ku, Kyoto 606-01, Japan;Department of Anatomy, Kansai Medical University, Moriguchi, Osaka 570, Japan
关键词: G-protein-coupled receptor;    Opioid receptor;    cDNA cloning;    RNA blot hybridization analysis;    Hybridization analysis (in situ);    Rat brain;    G-proteins;    guanine nucleotide-binding regulatory proteins;   
DOI  :  10.1016/0014-5793(94)80603-9
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

We have cloned a cDNA for a novel member of the opioid receptor family, designated as ROR-C, from the rat cerebrum cDNA library using the probe derived from the δ-opioid receptor subtype cDNA. The deduced amino acid sequence of ROR-C shows high homology with those of ROR-A (rat δ-opioid receptor subtype), ROR-B (rat μ-subtype) and ROR-D (rat k-subtype). RNA blot hybridization and in situ hybridization analysis revealed that ROR-C mRNA is expressed in discrete regions of the rat central nervous system.

【 授权许可】

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