Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

FEBS Letters

Takamatsu, Masako²  Onion, Akira²  Imahori, Kazutomo²  Uchida, Tsuneko²  Yonekura, Sayuri²  Kobayashi, Shunsuke¹  Ishiguro, Koichi²  Anzai, Kaijiro¹ 

[1] College of Pharmacy, Nihon University, Narashinodai, Funabashi-shi, Chiba 274, Japan;Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida-shi, Tokyo 194, Japan

关键词: Tau protein;    Paired helical filament;    Alzheimer's disease;    Cyclin-dependent kinase 5;    Tag sequence;   

DOI  :  10.1016/0014-5793(94)80501-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Tau protein kinase II (TPKII) was reported previously to be composed of a neuron-rich cdc2-related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2-related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.

【 授权许可】

Unknown