Two hypotheses ‐ one answer

FEBS Letters

Soppa, Jörg¹ 

[1] Max-Planck-Institut für Biochemie, Am Klopferspitz, 82152 Martinsried, Germany

关键词: G-protein-coupled receptor;    Bacteriorhodopsin;    Halorhodopsin;    Sensory rhodopsin;    Retinal protein;   

DOI  :  10.1016/0014-5793(94)80573-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The structure of bacteriorhodopsin (BR) of Halobacterium halobium is known. Despite the lack of sequence similarities it is often taken as a model for eukaryotic G-protein-coupled receptors (GPCRs). Recently two hypotheses were used to support the homology of BR and GPCRs, namly evolution by exon shuffling and evolution by gene duplication. BR is a member of a family of halobacterial retinal proteins. The sequences of eight members of this family were used to test the two hypotheses. Based on sequence comparison, no indication for an evolutionary linkage between the two protein families could be found.

【 授权许可】

Unknown