Mitochondrial respiratory chain inhibitors induce apoptosis

FEBS Letters

Krauer, Kenia¹  Johnson, Karina L.¹  Ralph, Steve J.¹  Linnane, Anthony W.¹  Wolvetang, Ernst J.¹ 

[1] Department of Biochemistry and Centre for Molecular Biology and Medicine, Monash University, Clayton, Vic. 3168, Australia

关键词: Human Lymphoblastoid cell;    Melanoma cell;    Proto-oncogene product Bcl-2;   

DOI  :  10.1016/0014-5793(94)80380-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In this paper the specific mitochondrial respiratory chain inhibitors rotenone and antimycin A and the highly specific mitochondrial ATP-synthase inhibitor oligomycin are shown to induce an apoptotic suicide response in cultured human lymphoblastoid and other mammalian cells within 12–18 h. The mitochondrial inhibitors do not induce apoptosis in cells depleted of mitochondrial DNA and thus lacking an intact mitochondrial respiratory chain. Apoptosis induced by respiratory chain inhibitors is not inhibited by the presence of Bcl-2. We discuss the possible role of mitochondrial induced apoptosis in the ageing process and age-associated diseases.

【 授权许可】

Unknown