Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells

FEBS Letters

Foecking, Mark F.²  Slominski, Andrzej¹  Gomez-Sanchez, Celso E.²  Wortsman, Jacobo³ 

[1] Department of Pathology, Medical Center, Loyola University, 2160 South First Avenue, Maywood, IL 60153, USA;Endocrine Section, Harry S. Truman Memorial Veterans Hospital and Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Missouri, Columbia, MO, USA;Department of Medicine, Southern Illinois University, Springfield, IL, USA

关键词: Steroid;    Melanoma cell;    Corticosterone;    11-Deoxycorticosterone;    Aldosterone;    18-Hydroxydeoxycorticosterone;    Progesterone;   

DOI  :  10.1016/S0014-5793(99)00889-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.

【 授权许可】

Unknown