期刊论文详细信息
FEBS Letters | |
Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells | |
Foecking, Mark F.2  Slominski, Andrzej1  Gomez-Sanchez, Celso E.2  Wortsman, Jacobo3  | |
[1] Department of Pathology, Medical Center, Loyola University, 2160 South First Avenue, Maywood, IL 60153, USA;Endocrine Section, Harry S. Truman Memorial Veterans Hospital and Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Missouri, Columbia, MO, USA;Department of Medicine, Southern Illinois University, Springfield, IL, USA | |
关键词: Steroid; Melanoma cell; Corticosterone; 11-Deoxycorticosterone; Aldosterone; 18-Hydroxydeoxycorticosterone; Progesterone; | |
DOI : 10.1016/S0014-5793(99)00889-3 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.
【 授权许可】
Unknown
【 预 览 】
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RO201912020308060ZK.pdf | 99KB | download |