期刊论文详细信息
FEBS Letters | |
Conversion of L‐tryptophan to serotonin and melatonin in human melanoma cells | |
Semak, Igor4  Szczesniewski, Andre1  Pisarchik, Alexander5  Slominski, Andrzej5  Wortsman, Jacobo2  Sweatman, Trevor3  | |
[1] Agilent Techologies, Schaumburg, IL 60173, USA;Department of Internal Medicine, Southern Illinois University, Springfield, IL 62794, USA;Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA;Department of Biochemistry, Belarus State University, Minsk 220080, Byelorussia;Department of Pathology, University of Tennessee Health Science Center, 899 Madison Avenue, Room 576M, Memphis, TN 38163, USA | |
关键词: Melanoma cell; Serotonin; Melatonin; N-Acetylserotonin; | |
DOI : 10.1016/S0014-5793(01)03319-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase. The presence of the products Ser, 5OH-tryptophan, N-acetylserotonin, melatonin (Mel), 5-methoxytryptamine and 5-methoxytryptophol was documented by liquid chromatography–mass spectrometry. Thus, human melanoma cells can synthesize and metabolize Ser and Mel.
【 授权许可】
Unknown
【 预 览 】
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RO201912020311388ZK.pdf | 149KB | download |