Timing of palmitoylation of influenza virus hemagglutinin

FEBS Letters

Veit, Michael¹  Schmidt, Michael F.G.¹ 

[1] Institut für Immunologie und Molekularbiologie, Freie Universität Berlin, Fachbereich Veterinärmedizin, Königin-Luise-Str. 49, 14195 Berlin, Germany

关键词: Influenza virus;    Hemagglutinin;    Intracellular transport;    Palmitoylation;    Oligomerisation;    Brefeldin A;   

DOI  :  10.1016/0014-5793(93)80812-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The timing of the attachment of fatty acids to the hemagglutinin (HA) of influenza A virus was studied. Treatment of virus infected cells with brefeldin A (BFA), a drug which blocks intracellular transport along the exocytic pathway at a pre-Golgi site, does not prevent palmitoylation of HA. The relationship of HA-palmitoylation to the oligomerisation and to the proteolytical cleavage of the protein revealed that the uncleaved trimer of HA is the substrate for the acylating enzyme in virus infected cells. The results are discussed with regard to the intracellular site of palmitoylation.

【 授权许可】

Unknown