FEBS Letters | |
Substitution of amino acid residue in influenza A virus hemagglutinin affects recognition of sialyl‐oligosaccharides containing N‐glycolylneuraminic acid | |
Fukunaga, Kyoko7  Ohuchi, Masanobu2  Miyamoto, Daisei6  Toyoda, Tetsuya4  Suzuki, Takashi6  Suzuki, Yasuo6  Ito, Toshihiro3  Jwa Hidari, Kazuya I.-P.6  Ishihama, Akira1  Kiso, Makoto7  Kawaoka, Yoshihiro8  Horiike, Goh6  Murakami, Kohji6  Sugiyama, Yoshikuni6  Kida, Hiroshi5  Masuda, Hiroyuki6  | |
[1] Department of Molecular Genetics, National Institute of Genetics, Mishima 411-8540, Japan;Department of Microbiology, Kawasaki Medical School, Kurashiki 701-0192, Japan;Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan;Department of Virology, Kurume University, School of Medicine, Kurume 830-0011, Japan;Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan;Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka 422-8526, Japan;Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-1193, Japan;Department of Pathobiological Science, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA | |
关键词: Influenza virus; Hemagglutinin; Sialic acid; Sialyl-oligosaccharide; N-Glycolylneuraminic acid; HA; hemagglutinin; HAU; hemagglutination unit; Neu5Ac; 5-N-acetylneuraminic acid; Neu5Gc; 5-N-glycolylneuraminic acid; TLC; thin-layer chromatography; RBS; receptor binding site; | |
DOI : 10.1016/S0014-5793(99)01575-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Sialic acids are essential components of cell surface receptors used by influenza viruses. To determine the molecular mechanisms of viral recognition of two major species of sialic acids, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), we tested the binding reactivity of nine human H3 influenza A viruses to sialylglycolipids containing type II sugar chain and different molecular species of terminal sialic acids. All human H3 viruses tested except A/Memphis/1/71 bound both Neu5Ac and Neu5Gc. Nucleotide sequence analysis suggests that amino acids at 143, 155, and 158 are linked to the viral recognition of Neu5Gc.
【 授权许可】
Unknown
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