Active increase in cardiolipin synthesis in the stationary growth phase and its physiological significance in Escherichia coli

FEBS Letters

Hiraoka, Shuichi¹  Shibuya, Isao¹  Matsuzaki, Hiroshi¹ 

[1] Department of Biochemistry, Saitama University, Urawa 338, Japan

关键词: Cardiolipin;    Cardiolipin synthase;    Cell survival;    Escherichia coli;    Stationary growth phase;   

DOI  :  10.1016/0014-5793(93)80807-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Activity of the Escherichia coli cardiolipin synthase, encoded by cls, increased about 10-fold in the stationary growth phase, while other committedstep enzymes in phospholipid biosynthesis rather decreased. A null cls mutant lost viability to 10⁻⁴ of the wild-type cells during the prolonged incubation for 5 days. Cardiolipin was most stable among membrane phospholipids during the incubation. Accordingly, cardiolipin should play a role in survival of the cell and E. coli employs a sophisticated way to form cardiolipin according to need even under non-growing conditions.

【 授权许可】

Unknown