Impaired gene transcription and nuclear protein kinase C activation in the brain and liver of aged rats

FEBS Letters

Ritz, Marie-Françoise¹  Malviya, Anant N.¹  Rogue, Patrick J.¹ 

[1] Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires (UPR 416 du CNRS), Centre de Neurochimie, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France

关键词: Aging;    Heat shock;    Nuclear PKC;    Gene transcription;   

DOI  :  10.1016/0014-5793(93)80710-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression of the hsp70 and c-fos genes and the activation of nuclear protein kinase C (PKC) were studied in young and aged whole rats under heat-shock conditions. The induction of hsp70 and c-fos genes by heat shock were decreased several fold in the brain as well as in the liver of senescent animals. Nuclear run-off transcription assay indicated that this age-related impairment could be attributed to a block at the level of transcription. Nuclear PKC activation by heat shock was not apparent in old animals. Nuclear PKC involvement in the repression of transcription during senescence is postulated.

【 授权许可】

Unknown