Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats

NEUROSCIENCE LETTERS

卷:472

Article

Gupte, Anisha A.¹  Morris, Jill K.¹  Zhang, Hongyu¹  Bomhoff, Gregory L.¹  Geiger, Paige C.^1,2,3  Stanford, John A.^1,2,3 

[1] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA

[2] Univ Kansas, Med Ctr, Smith Intellectual & Dev Disabil Res Ctr, Kansas City, KS 66160 USA

[3] Univ Kansas, Med Ctr, Landon Ctr Aging, Kansas City, KS 66160 USA

关键词: Heat shock;    Basal ganglia;    Aging;    Parkinsonism;    Neuroprotection;    Chaperones;    Stress;   

DOI  :  10.1016/j.neulet.2010.01.049

来源: Elsevier

【 摘 要 】

Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. Despite their protective role, little is known about HSP expression in the aging basal ganglia. The purpose of this study was to examine HSP expression in striatum, substantia nigra, globus pallidus and cortex in 6-, 18- and 30-month-old Fischer 344/Brown Norway rats. We found robust age-related increases in phosphorylated and total HSP25 in each brain region studied. Conversely, HSP72 (the inducible form of HSP70) was reduced with age, but only in the striatum. p38 MAPK, a protein implicated in activating HSP25, did not change with age, nor did HSC70 (the constitutive form of HSP70), or HSP60. These results suggest that HSP25 is especially responsive to age-related stress in the basal ganglia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free