Modulation of interleukin 2 high affinity binding to human T cells by a pyrimidodiazepine insect metabolite

FEBS Letters

Ziegler, Irmgard¹  Davis, Anthony P.²  Heaney, Frances M.²  Borchert, Monika¹  Boyle, Peter H.² 

[1] GSF-Institut für Klinische Molekularbiologie und Tümorgenetik, Munich, Germany;University Chemical Laboratory, Trinity College, Dublin 2, Ireland

关键词: Interleukin 2 receptor;    Tetrahydrobiopterin;    Homopterin;    Pyrimido[4;    5-b][l;    4]diazepine;    Molecular modelling;    Conformational analysis;   

DOI  :  10.1016/0014-5793(93)80700-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An insect metabolite containing the little known pyrimido[4,5-b][l,4]diazepine ring system has been found to act as an effective mimic of tetrahydrobiopterin in its ability to modulate the affinity of interleukin 2 (IL-2) for its receptors on human T cells. Semi-empirical molecular orbital calculations reveal that while tetrahydrobiopterin has considerable flexibility, the pyrimidodiazepine has rather few conformational options and offers a useful model for exploring the nature of the pterin binding site.

【 授权许可】

Unknown