Novel Tri- and Tetra-substituted Pyrimido[4,5-d]pyridazines: Regiospecific Synthesis Catalyzed by Silica Supported Yttrium Trinitrate

Bulletin of the Korean chemical society

Saeed Khodabakhshi¹  Sedigheh Akrami¹  Bahador Karami¹ 

关键词: Pyrimido[4;    5-d]pyridazines;    Silica supported yttrium trinitrate;    Hydrazine;    Solvent-free;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Novel tri- and tetra-substituted pyrimido[4,5-d]pyridazines-2(1H,3H,7H)-ones have been synthesized via the regiospecific condensation reaction of hydrazine derivatives with 5-acetyl-4-aryloyl-6-methyl-3,4-dihydropyrimidinones in the presence of SiO2-Y(NO3)3 as a green and recyclable catalyst under solvent-free conditions. All products were obtained in high yields and short reaction time. Employing this method is in accord with green chemistry principles.

【 授权许可】

Unknown