A Regiospecific One-Pot, Three Component Synthesis of 4-Aryl-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones as New Potential Monoamine Oxidase Inhibitors

Bulletin of the Korean chemical society

Jabbar Khalafy¹  Hossein Rabiei¹  Mehdi Rimaz¹  Leila Panahi¹ 

关键词: Pyrimido[4;    5-c]pyridazine;    Monoamine;    Arylglyoxal;    Barbituric acid;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A series of new 4-aryl-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones have been synthesized via three component reaction of 1,3-dimethylbarbituric acid with arylglyoxals in the presence of hydrazinium dihydrochloride in ethanol. All of these derivatives may act as potential monoamine oxidase inhibitors.

【 授权许可】

Unknown