Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin

FEBS Letters

Caocci, Fabio²  Zardi, Luciano²  Ponassi, Marco²  Siri, Annalisa²  Linnala, Auli¹  Balza, Enrica²  Virtanen, Ismo¹ 

[1] Department of Anatomy, University of Helsinki, Helsinki, Finland;Laboratory of Cell Biology, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV 10, 16132 Genoa, Italy

关键词: Tenascin;    Monoclonal antibody;   

DOI  :  10.1016/0014-5793(93)80479-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.

【 授权许可】

Unknown