Calcitonin gene expression in normal human liver

FEBS Letters

Pidoux, E.¹  Clement, B.³  Andreoletti, M.²  Machairas, M.¹  Jullienne, A.¹  Moukhtar, M.S.¹  Bracq, S.¹ 

[1] INSERM U349, Centre Viggo Petersen, 6 rue Guy Patin, 75010 Paris, France;INSERM Cjf 90.03, ICGM, 22 rue Méchain, 75014 Paris, France;INSERM U49, Hǒpital Pontchaillou, 35033 Rennes, France

关键词: Autocrine;    Paracrine;    Biosynthesis;    Calcitonin mRNA (human liver);    PCR;    CT;    calcitonin;    hCT;    human calcitonin;    Rnase;    ribonuclease A;    PCR;    polymerase chain reaction;    BSA;    bovine serum albumin;    SSC;    sodium saline citrate;   

DOI  :  10.1016/0014-5793(93)80288-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Immunoreactive calcitonin (CT) is present in liver. This could represent hormone synthesized by liver cells, degraded or bound to specific receptors reported in this organ. We report here that the calcitonin gene is expressed in liver. We proved this by demonstrating, by PCR amplification using specific primers, the presence of calcitonin messenger in human liver and in primary cultures of human hepatocytes and detected by radioimmunoassay CT in hepatic tissues and cells. The synthesis of hormone by liver that also possesses specific receptors for CT favors the presence of an autocrine or paracrine system involving calcitonin in this organ.

【 授权许可】

Unknown