Parathyroid hormone‐related peptide can regulate the growth of human lung cancer cells, and may form part of an autocrine TGF‐α loop

FEBS Letters

Burton, Paul B.J.¹  Knight, Derek E.¹ 

[1] Division of Biomedical Sciences, Kings College, London W8 7AH, UK

关键词: PTHrP;    TGF-α;    Lung cancer;    Autocrine;   

DOI  :  10.1016/0014-5793(92)80674-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Parathyroid hormone-related peptide (PTHrP) and transforming growth factor-α (TGF-α) were found to stimulate proliferation of human lung cancer cells (BEN-57). TGF-α stimulated PTHrP secretion from these cells. The polyclonal antisera raised against PTHrP significantly inhibited the growth of BEN-57 cells, and also the proliferation induced by TGF-α. Treatment of cells for up to 10 days with either a PTHrP receptor antagonist (PTHrP(7–34)) or PTHrP antiserum significantly inhibited the subsequent growth of these cells. We suggest that PTHrl may be a component of a complex autocrine loop involving TGF-α.

【 授权许可】

Unknown