Dp71, the nonmuscle product of the Duchenne muscular dystrophy gene is associated with the cell membrane

FEBS Letters

Greenberg, David S.¹  Tal, Michael¹  Yaffe, David¹  Rapaport, Debora¹  Nudel, Uri¹ 

[1] Department of Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel

关键词: Duchenne muscular dystrophy;    Dp71;    Dystrophin;    Immunostaining;    Plasma membrane;    DMD;    Duchenne muscular dystrophy;    kDa;    kilodalton;    DRP;    dystrophin related protein;    kb;    kilobase(s);    PM;    plasma membrane;    ER;    endoplasmie reticulum;    Ab(s) antibody(ies);    mAb;    monoclonal antibody;    pAb;    polyclonal antibody;   

DOI  :  10.1016/0014-5793(93)80992-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The 70.8 kDa protein, Dp71, is the major Duchenne muscular dystrophy (DMD) gene product in many nonmuscle tissues including the brain. Dp71 shares most of the C-terminal and cysteine-rich domains with the dystrophins but lacks the entire large rod shaped domain of spectrin-like repeats, and the N-terminal actin-binding domain. The function of Dp71 is unknown. Using subcellular fractionation and immunostaining we show that Dp71 is associated with the plasma membrane. Dp71 is also associated with the plasma membrane in mdx myogenic cells transfected with a vector expressing Dp71.

【 授权许可】

Unknown