FEBS Letters | |
N‐Acetylcysteine inhibits apoptosis and decreases viral particles in HIV‐chronically infected U937 cells | |
Malorni, Walter1  Rivabene, Roberto1  Donelli, Gianfranco1  Teresa Santini, Maria1  | |
[1] Department of Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy | |
关键词: Apoptosis; Human immunodeficiency virus (HIV); Tumor necrosis factor (TNF); Reactive oxygen intermediate (ROI); Reduced glutathione (GSH); N-Acetylcysteine (NAC); | |
DOI : 10.1016/0014-5793(93)81043-Y | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Apoptosis or programmed cell death (PCD) is a type of death occurring in various physiological processes. Several data suggest that: (1) apoptosis may play a critical role in AIDS pathogenesis; (2) an increase of endocellular free radical levels can be associated with activation of previously latent HIV virus. Tumor necrosis factor (TNF), a cytokine capable of inducing oxygen free radicals and apoptosis, appears also to be involved in HIV activation. The present findings, which elucidate a relationship between the percentage of apoptotic cells, reduced glutathione (GSH) depletion and an increase of p24 antigenemia, suggest that pretreatment with N-acetylcysteine (NAC) is capable of decreasing the above-mentioned phenomena in HIV-infected U937 cells.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020298156ZK.pdf | 559KB | download |