N‐Acetylcysteine inhibits apoptosis and decreases viral particles in HIV‐chronically infected U937 cells

FEBS Letters

Malorni, Walter¹  Rivabene, Roberto¹  Donelli, Gianfranco¹  Teresa Santini, Maria¹ 

[1] Department of Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy

关键词: Apoptosis;    Human immunodeficiency virus (HIV);    Tumor necrosis factor (TNF);    Reactive oxygen intermediate (ROI);    Reduced glutathione (GSH);    N-Acetylcysteine (NAC);   

DOI  :  10.1016/0014-5793(93)81043-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Apoptosis or programmed cell death (PCD) is a type of death occurring in various physiological processes. Several data suggest that: (1) apoptosis may play a critical role in AIDS pathogenesis; (2) an increase of endocellular free radical levels can be associated with activation of previously latent HIV virus. Tumor necrosis factor (TNF), a cytokine capable of inducing oxygen free radicals and apoptosis, appears also to be involved in HIV activation. The present findings, which elucidate a relationship between the percentage of apoptotic cells, reduced glutathione (GSH) depletion and an increase of p24 antigenemia, suggest that pretreatment with N-acetylcysteine (NAC) is capable of decreasing the above-mentioned phenomena in HIV-infected U937 cells.

【 授权许可】

Unknown