Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action

FEBS Letters

Wiseman, Helen¹ 

[1] Pharmacology Group, King's College, University of London, Manresa Road, London SW3 6LX, UK

关键词: Vitamin D;    Liposomal lipid peroxidation;    Anticancer action;    Tamoxifen;    Membrane antioxidant;    Cholesterol;   

DOI  :  10.1016/0014-5793(93)81809-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Vitamin D is a membrane antioxidant: thus Vitamin D₃ (cholecalciferol) and its active metabolite 1,25-dihydroxycholecalciferol and also Vitamin D₂ (ergocalciferol) and 7-dehydrocholesterol (pro-Vitamin D₃) all inhibited iron-dependent liposomal lipid peroxidation. Cholecalciferol, 1,25-dihydroxycholecalciferol and ergocalciferol were all of similar effectiveness as inhibitors of lipid peroxidation but were less effective than 7-dehydrocholesterol; this was a better inhibitor of lipid peroxidation than cholesterol, though not ergosterol. The structural basis for the antioxidant ability of these Vitamin D compounds is considered in terms of their molecular relationship to cholesterol and ergosterol. Furthermore, the antioxidant ability of Vitamin D is compared to that of the anticancer drug tamoxifen and its 4-hydroxy metabolite (structural mimics of cholesterol) and discussed in relation to the anticancer action of this vitamin.

【 授权许可】

Unknown