Carcinogenic antioxidants

FEBS Letters

Wiseman, Helen¹  Halliwell, Barry¹ 

[1] Pharmacology Group, King's College, University of London, Manresa Road, London, SW3 6LX, UK

关键词: Antioxidant;    Lipid peroxidation;    Carcinogenic action;    Diethylstilboestrol;    Anticancer action;    Tamoxifen;   

DOI  :  10.1016/0014-5793(93)80504-N

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The synthetic oestrogens diethylstilboestrol, hexoestrol and 17 α-ethynyloestradiol are known to be carcinogenic, yet they all exert antioxidant properties in vitro in that they are good inhibitors of iron ion-dependent lipid peroxidation. In rat liver microsomes incubated with Fe(III)-ascorbate or Fe(III)-ADP/NADPH and also in ox-brain phospholipid liposomes incubated with Fe(III)-ascorbate; the overall order of effectiveness of the compounds tested as inhibitors of lipid peroxidation was diethylstilboestrol ⪢ hexoestrol ⪢ 17 α-ethynyloestradiol ⪢ 4-hydroxytamoxifen ⪢ 17 β-oestradiol ⪢ tamoxifen. Compounds acting as antioxidants towards lipids may also exert pro-oxidant effects towards other molecules such as DNA and thus must never be assumed to be safe for human use.

【 授权许可】

Unknown