Tamoxifen and related compounds decrease membrane fluidity in liposomes

FEBS Letters

Wiseman, Helen¹  Quinn, Peter²  Halliwell, Barry¹ 

[1] Pharmacology Group, Biomedical Sciences Division, King's College, University of London, Manresa Road, London SW3 6LX, UK;Division of Life Sciences, King's College, University of London, Campden Hill, London W8 7 AH, UK

关键词: Membrane fluidity;    Tamoxifen;    Antioxidant action;    Liposomal lipid peroxidation;    Anticancer action;    Cardioprotectant;   

DOI  :  10.1016/0014-5793(93)80918-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Tamoxifen and related compounds decrease membrane fluidity in ox-brain phospholipid liposomes: their order of effectiveness is, 4-hydroxytamoxifen > 17β-oestradiol > tamoxifen >cis-tamoxifen >N-desmethyltamoxifen > cholesterol. A good positive correlation was demonstrated between the decrease in membrane fluidity by these compounds and their antioxidant ability as inhibitors of liposomal and microsomal lipid peroxidation (correlation coefficient, r = 0.99, P < 0.001, in both cases). The ability of tamoxifen to decrease membrane fluidity is suggested to be the mechanism of its antioxidant action and is discussed in relation to its anticancer and cardioprotective actions.

【 授权许可】

Unknown