Expression of synaptotagmin and syntaxin associated with N‐type calcium channels in small cell lung cancer

FEBS Letters

Seagar, Michael J.³  Takahashi, Masami¹  David, Pascale³  El Far, Oussama³  Poupon, Marie France²  Martin-Mouto, Nicole³ 

[1] Mitsubishi Kasei Institute of Life Science, Machida-shi, Tokyo, Japan;Institut Curie, Rue d'Ulm, Paris, France;INSERM U374, Faculté de Medecine Secteur Nord, Bd. Pierre Dramard, 13916 Marseille Cedex 20, France

关键词: ω-Conotoxin;    Calcium channel;    Synaptotagmin;    Syntaxin;    HPC-1;    Small cell lung cancer;   

DOI  :  10.1016/0014-5793(93)81777-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N-Type calcium channels (ω)-conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC-1) were detected in eight. Co-immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.

【 授权许可】

Unknown