α‐Latrotoxin receptor

FEBS Letters

Petrenko, Alexander G.¹ 

[1] Research Center of Molecular Diagnostics and Therapy, 113149, Moscow, Russian Federation

关键词: Neurotransmitter release;    α-Latrotoxin;    Neurexin;    Synaptic vesicle;    Synaptotagmin;   

DOI  :  10.1016/0014-5793(93)81418-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

α-Latrotoxin is a potent stimulator of neurotransmitter release from nerve terminals. High affinity membrane α-latrotoxin receptor was purified in an active binding form. It is a membrane glycoprotein (M _r 160,000–220,000) which may be complexed to a smaller polypeptide (M _r 29,000). The structure of the receptor protein suggests that it may be a synapse-specific cell recognition molecule. Intracellularly, the α-latrotoxin receptor interacts with synaptotagmin, a calcium- and phospholipid-binding protein specifically localized in the synaptic vesicle membrane. This interaction may be important for targeting of synaptic vesicles to presynaptic release sites.

【 授权许可】

Unknown