Irsogladine is a potent inhibitor of angiogenesis

FEBS Letters

Kuwano, Michihiko²  Sato, Yasufumi¹  Sakata, Toshiie¹  Morimoto, Akio²  Hamanaka, Ryoji²  Kohno, Kimitoshi²  Kiue, Akira²  Okamura, Kazuki² 

[1] Department of Internal Medicine 1 Oita Medical University, Idaigaoka 1-1, Hasama-machi, Oita, Japan;Department of Biochemistry, Oita Medical University, Idaigaoka 1-1, Hasama-machi, Oita, Japan

关键词: Angiogenesis;    Plasminogen activator;    Irsogladine;   

DOI  :  10.1016/0014-5793(93)81558-H

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.

【 授权许可】

Unknown