Human neuroblastoma cells produce the NF‐kB‐like HIV‐1 transcription activator during differentiation

FEBS Letters

Ueno, Ryuji¹  Ito, Yasuhiro³  Kurata, Nori³  Wakabayashi, Teruko¹  Kurata, Shun-ichi²  Marunouchi, Tohru³  Miwa, Naoto¹ 

[1] Ueno Institute for Medical Science, Ueno Fine Chemicals Industry Ltd., Techno-Park 4-1, Sanda, Hyogo 669-13, Japan;Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113, Japan;Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-11, Japan

关键词: NF-kB;    Neuroblastoma;    HIV-1;    AIDS;    Nerve cell differentiation;   

DOI  :  10.1016/0014-5793(93)80108-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human neuroblastoma GOTO and IMR32 cells differentiate into neural cells on treatment with 5-BrdU. Here we report that in association with differentiation induced by 5-BrdU, the transcription of HIV-1 was activated in both neuroblastoma cell lines. An NF-kB-like factor was also found to be produced in association with the neural cell differentiation of these cells. These results suggest that, during differentiation of neural cells, an NF-kB-like factor was produced, and that when the neural cells are infected with HIV-1 the production of NF-kB results in activation of transcription of HIV-1. Thus this NF-kB-like factor may be involved in the mechanism causing AIDS dementia.

【 授权许可】

Unknown