Identification and differential expression of yeast SEC23‐related gene (Msec23) in mouse tissues

FEBS Letters

Sugimoto, Yoshikazu²  Ikawa, Yoji²  Sarai, Akinori³  Kaul, Sunil C.¹  Komatsu, Yasuhiko¹  Wadhwa, Renu² 

[1] Fermentation Research Institute, Agency of Industrial Science and Technology, Tsukuba, Ibaraki 305, Japan;Laboratory of Molecular Oncology Tsukuba Life Science Center, The Institute of Physical and Chemical Research, Koyadai, Tsukuba, Ibaraki 305, Japan;Laboratory of Gene Bank, Tsukuba Life Science Center, The Institute of Physical and Chemical Research, Koyadai, Tsukuba, Ibaraki 305, Japan

关键词: Yeast SEC23-related gene;    cDNA sequence;    Differential tissue expression;   

DOI  :  10.1016/0014-5793(93)81161-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have isolated a yeast SEC23-related clone (Msec23) from mouse fibroblast cDNA library. It has an open reading frame of 1721 bp (64% homologous to SEC23-2.3 kb) which can potentially encode a 64.7 kDa protein (61% homologous to 85.4 kDa product of SEC23). The deduced Msec23 protein (Msec23p) sequence contains three successive Ig-like domains at the N-terminus followed by amphipathic α-helical regions, suggesting the potential of Msec23p to interact with other protein components. Further, Msec23 is differentially expressed in mouse tissues with its high level in brain and fibroblasts.

【 授权许可】

Unknown