Absence of expression of interleukin‐6 (IL‐6) mRNA in regenerating rat liver

FEBS Letters

Lebreton, Jean-Pierre¹  Scotté, Michel¹  Daveau, Maryvonne¹  Hiron, Martine¹  Ténière, Paul¹ 

[1] INSERM Unité 78, BP 73, 76233 Bois-Guillaume Cedex, France

关键词: Interleukin-6;    Hepatic regeneration;    Rat;   

DOI  :  10.1016/0014-5793(93)81154-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The serum level of IL-6 and expression of IL-6 mRNA in hepatocytes from regenerating liver were investigated in the rat. The IL-6 level in the serum was not significantly different from that of a control group of rats submitted to an acute experimental inflammation. IL-6 mRNA expression did not occur in the liver of hepatectomized rats as judged from Northern blotting experiments using an IL-6 riboprobe. These results suggest that if IL-6 is implicated in hepatic regeneration, this cytokine is not produced by the regenerating liver and must be delivered exogenously to the liver to modulate hepatic regeneration.

【 授权许可】

Unknown