FEBS Letters | |
A voltage‐gated calcium channel is linked to the antigen receptor in Jurkat T lymphocytes | |
Szabo, Gabor2  Gray, Lloyd S.1  Densmore, John J.1  | |
[1] Interdisciplinary Graduate Program in Biophysics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA;Department of Physiology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA | |
关键词: Electrophysiology; T lymphocyte; Calcium channel; Activation; Antigen receptor; | |
DOI : 10.1016/0014-5793(92)80926-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Activation of T lymphocytes results in an increase in intracellular Ca2+ due in large part to influx of extracellular Ca2+. Using the patch clamp technique, an inward current in Jurkat T lymphocytes was observed upon depolarization from a holding potential of −90 mV but not from −60 mV. This whole-cell current was insensitive to tetrodotoxin, carried by Ba2+, and blocked by Ni2+. Occupancy of the T lymphocyte antigen receptor increased the current's magnitude. These data suggest that antigen receptor-induced Ca2+ entry in T lymphocytes may be mediated by a voltage-regulated Ca channel.
【 授权许可】
Unknown
【 预 览 】
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