FEBS Letters | |
A family of γ‐like calcium channel subunits | |
Klugbauer, Norbert1  Lacinová, Lubica1  Hofmann, Franz1  Marais, Elsé1  Specht, Verena1  Bohn, Georg1  Dai, Shuiping1  | |
[1] Institut für Pharmakologie und Toxikologie der Technischen Universität München, Biedersteiner Str. 29, 80802 Munich, Germany | |
关键词: Calcium channel; Gamma subunit; Voltage gated; Molecular diversity; Electrophysiology; | |
DOI : 10.1016/S0014-5793(00)01306-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The γ subunit was initially identified as an auxiliary subunit of the skeletal muscle calcium channel complex. Evidence for the existence of further γ subunits arose following the characterization of a genetic defect that induces epileptic seizures in stargazer mice. We present here the first account of a family of at least five putative γ subunits that are predominantly expressed in brain. The γ-2 and γ-4 subunits shift the steady-state inactivation curve to more hyperpolarized potentials upon coexpression with the P/Q type α1A subunit. The coexpression of the γ-5 subunit accelerates the time course of current activation and inactivation of the α1G T-type calcium channel.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020309150ZK.pdf | 489KB | download |