A family of γ‐like calcium channel subunits

FEBS Letters

Klugbauer, Norbert¹  Lacinová, Lubica¹  Hofmann, Franz¹  Marais, Elsé¹  Specht, Verena¹  Bohn, Georg¹  Dai, Shuiping¹ 

[1] Institut für Pharmakologie und Toxikologie der Technischen Universität München, Biedersteiner Str. 29, 80802 Munich, Germany

关键词: Calcium channel;    Gamma subunit;    Voltage gated;    Molecular diversity;    Electrophysiology;   

DOI  :  10.1016/S0014-5793(00)01306-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The γ subunit was initially identified as an auxiliary subunit of the skeletal muscle calcium channel complex. Evidence for the existence of further γ subunits arose following the characterization of a genetic defect that induces epileptic seizures in stargazer mice. We present here the first account of a family of at least five putative γ subunits that are predominantly expressed in brain. The γ-2 and γ-4 subunits shift the steady-state inactivation curve to more hyperpolarized potentials upon coexpression with the P/Q type α_1A subunit. The coexpression of the γ-5 subunit accelerates the time course of current activation and inactivation of the α_1G T-type calcium channel.

【 授权许可】

Unknown