Expression of T‐ and L‐type calcium channel mRNA in murine sinoatrial node

FEBS Letters

Klugbauer, Norbert¹  Conrad, Heinke¹  Hofmann, Franz¹  Ludwig, Andreas¹  Moosmang, Sven¹  Bohn, Georg¹ 

[1] Institut für Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Straße 29, 80802 Munich, Germany

关键词: Electrophysiology;    Calcium channel;    T-type;    L-type;    In-situ hybridization;    Cardiac ion channel;   

DOI  :  10.1016/S0014-5793(00)01979-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

At the cellular level, cardiac pacemaking which sets the rate and rhythm of the heartbeat is produced by the slow diastolic depolarization. Several ion channels contribute to this pacemaker depolarization, including T-type and L-type calcium currents. To evaluate the molecular basis of the currents involved, we investigated the cellular distribution of various low voltage activated (LVA) and high voltage activated (HVA) calcium channel mRNAs in the murine sinoatrial (SA) node by in-situ hybridization. The most prominently expressed LVA calcium channel in the SA node is Ca_v3.1, whereas Ca_v3.2 is present at moderate levels. The dominant HVA calcium channel transcript is Ca_v1.2; only traces of Ca_v1.3 mRNA are detectable in SA myocytes of mice.

【 授权许可】

Unknown