Malarial toxic antigens synergistically enhance insulin signalling

FEBS Letters

Playfair, John H.L.¹  Saggerson, E.David²  Carr, Rachel¹  Taylor, Kathryn¹ 

[1] Department of Immunology, University College and Middlesex School of Medicine, London W1P 9PG, UK;Department of Biochemistry and Molecular Biology, University College London, Gower Street, London W1E 6BT, UK

关键词: Adipocyte;    Blood glucose;    Insulin;    Lipogenesis;    Lipolysis;    Malaria;   

DOI  :  10.1016/0014-5793(92)81109-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Hypoglycaemia is a major complication of severe malaria [(1990) Trans. Roy. Soc. Trop. Med. 84 (suppl. 2) 1–65], especially cerebral malaria, in which it is associated with increased mortality [(1990) Lancet 336, 1039–1043; (1989) Quart. J. Med. (New series) 71, 441–459]; however, the mechanisms responsible have not been fully explained. Preparations containing toxic malaria antigens (TMA) released by blood stage Plasmodium yoelii malaria parasites have been shown to induce hypoglycaemia in mice lasting at least 8 h [(1992) Clin. Exp. Immunol. (in press)]. Here we report that TMAs can act synergistically with insulin in both stimulating lipogenesis and inhibiting lipolysis in rat adipocytes in vitro, and, furthermore, that they act synergistically with insulin in the induction of hypoglycaemia in vivo.

【 授权许可】

Unknown