Induction of Ca2+/calmodulin‐dependent NO synthase in various organs of rats by Propionibacterium acnes and lipopolysaccharide treatment

FEBS Letters

Adachi, Hiroko¹  Ohshima, Hiroshi¹  Esumi, Hiroyasu¹  Iida, Sachio¹  Oguchi, Shinobu¹ 

[1] Biochemistry Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo, Japan

关键词: Nitric oxide;    NO synthase;    Calmodulin-dependent NO synthase;    Inducible;    Rat;    Lipopolysaccharide;   

DOI  :  10.1016/0014-5793(92)81041-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ca²⁺/calmodulin-dependent nitric oxide synthase was found to be induced during rat liver necrosis caused by administration of Propionibacterium acnes and E. coli lipopolysaccharide to rats. Examination of the specific induction of C^a2+/calmodulin-dependent NO synthase showed that the enzyme was induced in the lung, spleen and colon as well as the liver. Northern blot analysis revealed that the induction occurred at the transcriptional level.

【 授权许可】

Unknown