Molecular cloning and characterization of a novel calcium channel from rabbit brain

FEBS Letters

Friedrich, Thomas¹  Niidome, Tetsuhiro¹  Kim, Man-Suk¹  Mori, Yasuo¹ 

[1] Departments of Medical Chemistry and Molecular Genetics, Kyoto University Faculty of Medicine, Kyoto 606-01, Japan

关键词: Calcium channel;    cDNA cloning;    Nucleotide sequence;    RNA blot hybridization;    Rabbit brain;    DHP;    dihydropyridine;    ω-CgTx;    ω-conotoxin;   

DOI  :  10.1016/0014-5793(92)81038-N

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The complete amino acid sequence of a novel calcium channel (designated BII) from rabbit brain has been deduced by cloning and sequencing the cDNA. The BII calcium channel is structurally more closely related to the BI calcium channel than to the cardiac and skeletal muscle L-type calcium channels. Blot hybridization analysis of RNA from different tissues and from different regions of the brain shows that the BII calcium channel is distributed predominantly in the brain, being abundant in the cerebral cortex, hippocampus and corpus striatum.

【 授权许可】

Unknown