期刊论文详细信息
FEBS Letters | |
Loss of transcriptional repression contributes to the ectopic expression of the calcitonin/α‐CGRP gene in a human lung carcinoma cell line | |
Brickell, Paul M.1  Symes, Aviva J.1  Craig, Roger K.1  | |
[1] Medical Molecular Biology Unit, University College and Middlesex School of Medicine, Windeyer Building, Cleveland Street, London WC1B 8Y, UK | |
关键词: Calcitonin; CGRP; Transcription; Repression; Ectopic expression; | |
DOI : 10.1016/0014-5793(92)81006-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The calcitonin/α-CORP (CT/CGRP) gene is ectopically expressed in a wide variety of neoplasia. We have investigated the molecular mechanisms responsible for this ectopic expression in the human cell line BEN, which is derived from a poorly differentiated squamous cell lung carcinoma. We show that a trans-acting factor which represses expression of the CT/CGRP gene in HeLa cells is absent or inactive in BEN cells, and have localised the repressor binding site to a 53 bp fragment 1500 bp upstream of the transcription start site.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020296554ZK.pdf | 418KB | download |