Loss of transcriptional repression contributes to the ectopic expression of the calcitonin/α‐CGRP gene in a human lung carcinoma cell line

FEBS Letters

Brickell, Paul M.¹  Symes, Aviva J.¹  Craig, Roger K.¹ 

[1] Medical Molecular Biology Unit, University College and Middlesex School of Medicine, Windeyer Building, Cleveland Street, London WC1B 8Y, UK

关键词: Calcitonin;    CGRP;    Transcription;    Repression;    Ectopic expression;   

DOI  :  10.1016/0014-5793(92)81006-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The calcitonin/α-CORP (CT/CGRP) gene is ectopically expressed in a wide variety of neoplasia. We have investigated the molecular mechanisms responsible for this ectopic expression in the human cell line BEN, which is derived from a poorly differentiated squamous cell lung carcinoma. We show that a trans-acting factor which represses expression of the CT/CGRP gene in HeLa cells is absent or inactive in BEN cells, and have localised the repressor binding site to a 53 bp fragment 1500 bp upstream of the transcription start site.

【 授权许可】

Unknown