Structure and expression of the human calcitonin/CGRP genes

FEBS Letters

Lips, C.J.M.¹  Jansz, H.S.¹  Visser, A.¹  Steenbergh, P.M.¹  Zandberg, J.¹  Höppener, J.W.M.¹ 

[1] Institute of Molecular Biology, Padualaan 8, 3508 TB Utrecht, The Netherlands

关键词: Calcitonin CGRP Gene family Alternative splicing (Human);   

DOI  :  10.1016/0014-5793(86)81091-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recently, we have reported the isolation of cDNA encoding a second human calcitonin gene-related peptide (hCGRP-II) [(1985) FEBS Lett. 183, 403-407]. In this report we describe the isolation and characterization of the gene encoding hCGRP-II. This gene, designated CALC-II, is structurally closely related to the known CALC-I gene encoding human calcitonin (hCT) and hCGRP-I. In constrast to CALC-I, CALC-II does not seem to be alternatively expressed. The formation of a second, hCT-like mRNA by differential splicing of CALC-II transcripts is unlikely in view of the structure of CALC-II, and could not be demonstrated in tissues known to express CALC-I and CALC-II.

【 授权许可】

Unknown