FEBS Letters | |
Structure and expression of the human calcitonin/CGRP genes | |
Lips, C.J.M.1  Jansz, H.S.1  Visser, A.1  Steenbergh, P.M.1  Zandberg, J.1  Höppener, J.W.M.1  | |
[1] Institute of Molecular Biology, Padualaan 8, 3508 TB Utrecht, The Netherlands | |
关键词: Calcitonin CGRP Gene family Alternative splicing (Human); | |
DOI : 10.1016/0014-5793(86)81091-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Recently, we have reported the isolation of cDNA encoding a second human calcitonin gene-related peptide (hCGRP-II) [(1985) FEBS Lett. 183, 403-407]. In this report we describe the isolation and characterization of the gene encoding hCGRP-II. This gene, designated CALC-II, is structurally closely related to the known CALC-I gene encoding human calcitonin (hCT) and hCGRP-I. In constrast to CALC-I, CALC-II does not seem to be alternatively expressed. The formation of a second, hCT-like mRNA by differential splicing of CALC-II transcripts is unlikely in view of the structure of CALC-II, and could not be demonstrated in tissues known to express CALC-I and CALC-II.
【 授权许可】
Unknown
【 预 览 】
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