Selective inhibition of membrane fusion events in echinoderm gametes and embryos by halenaquinol sulfate

FEBS Letters

Ozaki, Yoshihiro¹  Kajiyama, Noboru¹  Myotoishi, Yuki¹  Kitagawa, Isao²  Takayama, Seiji³  Miyashiro, Shigeyoshi³  Ikegami, Susumu¹  Kobayashi, Motomasa³ 

[1] Department of Applied Biochemistry, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima, Hiroshima 724, Japan;Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565, Japan;Central Research Laboratories, Ajinomoto Co., 1-1 Suzuki-cho, Kawasaki, Kanagawa 210, Japan

关键词: Halenaquinol sulfate;    Membrane fusion;    Hatching;    Asterina pectinifera;   

DOI  :  10.1016/0014-5793(92)80460-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Halenaquinol sulfate, a hydroquinone sulfate obtained from the sponge Xestospongia sapra, prevented cell membrane fusion events of echinaderm gametes but did not affect early embryonic development of fertilized eggs up to the gastrula stage. However, halenaquinol sulfate inhibited secretion of hatching enzyme, resulting in the formation of gastrulae that were surrounded by the fertilization envelope. Therefore, the use of halenaquinol sulfate offers a unique opportunity to analyze the role of secretory events in complex populations of cells without affecting other cellular functions.

【 授权许可】

Unknown