Curcumin inhibits nitrite‐induced methemoglobin formation

FEBS Letters

Unnikrishnan, M.K.¹  Rao, M.N.A.¹ 

[1] Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal 576 119, India

关键词: Curcumin;    Methemoglobin formation inhibition;    Nitrite-induced methemoglobin;    Antioxidant;   

DOI  :  10.1016/0014-5793(92)81246-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Curcumin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when curcumin is added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of curcumin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.

【 授权许可】

Unknown