(HX) nrepeats: a pH‐controlled protein—protein interaction motif of eukaryotic transcription factors?

FEBS Letters

Sander, Chris¹  Janknecht, Ralf²  Pongs, Olaf³ 

[1]European Molecular Biology Laboratory, Meyerhofstrasse 1, D-6900 Heidelberg, Germany

[2]Institut für Molekularbiologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, D-3000 Hannover, Germany

[3]Lehrstuhl für Biochemie, Ruhr-Universität Bochum, Universitätsstrasse 150, D-4630 Bochum, Germany

关键词: Gene regulation;    Transcription factor;    Dimerization;    Zn-binding;    Sequence analysis;   

DOI  :  10.1016/0014-5793(91)81369-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A characteristic sequence repeat of type His-X, repeated several times in a row, is present in several eukaryotic transcription factors, e.g. HPHAHPHP in paired protein. Detailed molecular modelling and database searches lead to the suggestion that (HX) _n repeats can mediate interaction between transcription factors in a pH-controlled fashion.

【 授权许可】

Unknown