POMC gene expression in mouse and hamster melanoma cells

FEBS Letters

Slominski, Andrzej¹ 

[1] Department of Immunology and Microbiology, Albany Medical College, Albany, NY 12202, USA

关键词: Proopiomelanocortin;    β-Endorphin;    Melanoma;   

DOI  :  10.1016/0014-5793(91)81274-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Expression of mRNA hybridizable to murine POMC cDNA, and immunoreactivity specific for POMC derived peptide, β-endorphin, are reported for the first time in one murine and two hamster melanoma lines. The apparent sizes of POMC mRNA transcript were 3.5, 1.5 and 1 kb. It is suggested that POMC gene expression may be involved in the autoregulation of the melanoma phenotype at the cellular and tissue levels.

【 授权许可】

Unknown