Interaction of ACTH, β‐endorphin and α‐melanocyte stimulating hormone in relation to the corticosteroid production of isolated rat adrenocortical zona fasciculata and zona glomerulosa cells

FEBS Letters

Folly, Gábor¹  Szalay, Katalin Sz.¹ 

[1] Institute of Experimental Medicine, Hungarian Academy, of Sciences H-1450 Budapest, POB 67, Hungary

关键词: ACTH;    β-Endorphin;    α-MSH;    Proopiomelanocortin;    Adrenocortical Steroidogenesis;    Aldosterone;   

DOI  :  10.1016/0014-5793(92)80409-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The combined effects of ACTH, β-endorphin (β-EP) and α-MSH were studied on the corticosteroidogenesis or isolated rat adrenocortical zona fasciculata and zona glomerulosa cells. β-EP potentiated the effects of ACTH and α-MSH on the zona fasciculata corticosterone production but inhibited those on the zona glomerulosa aldosterone production. β-EP did not affect the combined action of 4×10⁻¹¹ M ACTH and 5×10⁻⁹ M α-MSH on the zona fasciculata or the zona glomerulosa cells, but it inhibited the stimulatory action of the combination of 1.6×10⁻¹⁰ M ACTH and 10⁻⁹ M α-MSH on the zona glomerulosa aldosterone production. An interaction of ACTH, β-EP and α-MSH in relation to the zona fasciculata and zona glomerulosa corticosteroid production was found.

【 授权许可】

Unknown