FEBS Letters | |
Effects of cholesterol‐ or 7‐ketocholesterol‐containing liposomes on colony‐forming ability of cultured cells | |
Ivanov, Aleksey S.1  Prokhorov, Leonid Yu.2  Archakov, Alexander I.1  Khokhlov, Alexander N.2  | |
[1] Institute of Biological and Medical Chemistry, Academy of Medical Sciences, Moscow, USSR;Evolutionary Cytogerontology Sector, Faculty of Biology, Moscow State University, Moscow, USSR | |
关键词: Cholesterol; 7-Ketocholesterol; Liposome; Cultured cell; Colony-forming ability; | |
DOI : 10.1016/0014-5793(91)81252-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Experiments with cultured Chinese hamster cells showed that incubation of the cells with (phosphatidylcholine + cholesterol + 7-ketocholesterol)-containing liposomes (4:3:1 by weight) during two hours led to a decrease in the colony-forming ability of cells down to zero, while (phosphatidylcholine + cholesterol)-containing liposomes (1:1 by weight) reduce this parameter by 90%. Furthermore, the cholesterol-containing liposomes (without 7-ketocholesterol) induce a decrease in the number of the maximal-site colonies accompanied by the corresponding increase in the number of the middle-size colonies.
【 授权许可】
Unknown
【 预 览 】
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