TPA‐induced activation of MAP kinase

FEBS Letters

Adams, Peter D.¹  Parker, Peter J.¹ 

[1] Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK

关键词: MAP kinase;    Protein kinase C;    Phorbol ester;    MAP-2;    microtubule-associated protein 2;    MAP kinase;    mitogen-activated kinase;    MBP;    myelin basic protein;    PBS;    phosphate-buffered saline;    PKC;    protein kinase C;    PP2A;    protein phosphatase 2A;    TPA;    tetradecanoyl phorbol acetate;   

DOI  :  10.1016/0014-5793(91)81230-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Threonine and tyrosine residue phosphorylation of a 42 kDa protein identified as mitogen-activated protein kinase (MAP kinase) was stimulated in extracts from TPA-pretreated cells. It is further shown that TPA pretreatment leads to the enhancement of an activity that will induce reactivation of dephosphorylated/inactivated MAP kinase. This TPA-induced activity induces the threonine and tyrosine phosphorylation of p42 in extracts from unstimulated cells.

【 授权许可】

Unknown