期刊论文详细信息
FEBS Letters | |
TPA‐induced activation of MAP kinase | |
Adams, Peter D.1  Parker, Peter J.1  | |
[1] Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK | |
关键词: MAP kinase; Protein kinase C; Phorbol ester; MAP-2; microtubule-associated protein 2; MAP kinase; mitogen-activated kinase; MBP; myelin basic protein; PBS; phosphate-buffered saline; PKC; protein kinase C; PP2A; protein phosphatase 2A; TPA; tetradecanoyl phorbol acetate; | |
DOI : 10.1016/0014-5793(91)81230-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Threonine and tyrosine residue phosphorylation of a 42 kDa protein identified as mitogen-activated protein kinase (MAP kinase) was stimulated in extracts from TPA-pretreated cells. It is further shown that TPA pretreatment leads to the enhancement of an activity that will induce reactivation of dephosphorylated/inactivated MAP kinase. This TPA-induced activity induces the threonine and tyrosine phosphorylation of p42 in extracts from unstimulated cells.
【 授权许可】
Unknown
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