How does protein synthesis give rise to the 3D‐structure?

FEBS Letters

Ptitsyn, O.B.¹ 

[1] Institute of Protein Research, Academy of Sciences of the USSR, 142292 Pushchino, Moscow Region, USSR

关键词: Protein folding;    Molten globule;    Kinetic intermediate;    NMR of protein;    Tertiary fold;   

DOI  :  10.1016/0014-5793(91)80799-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The recent experimental data on stages and kinetic intermediates in protein folding are reviewed. It is emphasized that these data are consistent with the ‘framework model’ proposed by the author in 1973. The model implies that protein folds by stage mechanism (secondary structure — molten globule state — native state) in such a way that the results of previous stages are not reconsidered in subsequent ones. Arguments are presented that both these hypotheses and available experimental data do not contradict the assumption that native structures of at least small proteins are nevertheless under thermodynamic rather than kinetic control, i.e. correspond to global minima of free energy.

【 授权许可】

Unknown