Change of intracellular calcium of neural cells induced by extracellular ATP

FEBS Letters

Tomura, Hideaki¹  Kondo, Yoichi¹  Hirano, Yukiko¹  Majid, Mohammed Abdul¹  Takeuchi, Toshiyuki¹  Okajima, Fumikazu¹ 

[1] Institute of Endocrinology, Gunma University, Maebashi 371, Japan

关键词: ATP;    Neural cell line;    Intracellular calcium;    Inositol trisphosphate;   

DOI  :  10.1016/0014-5793(91)80693-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Exposure of various neural cells to ATP increased intracellular Ca²⁺ and the production of inositol trisphosphate. The Ca²⁺ responses were also observed in the absence of extracellular Ca²⁺, suggesting that a part of Ca²⁺ mobilization took place from cytosolic storage. Since adenosine had no effect on intracellular Ca²⁺ increment, ATP appears to act through a P₂-purinergic receptor. Islet-activating protein or pertussis toxin pretreatment hardly influenced the increase in intracellular Ca²⁺ and inositol trisphosphate production induced by ATP, suggesting that IAP-sensitive GTP-binding proteins do not play a practical role in this reaction.

【 授权许可】

Unknown